View source for Androst-4-ene-3,17-dione monooxygenase

{{infobox enzyme
| Name       = androst-4-ene-3,17-dione monooxygenase
| EC_number  = 1.14.99.12
| CAS_number = 37256-74-9
| GO_code    = 0047096
| image      =
| width      = 
| caption    =  
}}

In [[enzymology]], an '''androst-4-ene-3,17-dione monooxygenase''' ({{EC number|1.14.99.12}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:androst-4-ene-3,17-dione + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H<sub>2</sub>O

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[androst-4-ene-3,17-dione]], an [[electron acceptor]] AH<sub>2</sub>, and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone]], the reduction product A, and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous.  The [[List of enzymes|systematic name]] of this enzyme class is '''androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing)'''. Other names in common use include '''androstene-3,17-dione hydroxylase''', '''androst-4-ene-3,17-dione 17-oxidoreductase''', '''androst-4-ene-3,17-dione hydroxylase''', '''androstenedione monooxygenase''', and '''4-androstene-3,17-dione monooxygenase'''.  This enzyme participates in [[androgen and estrogen metabolism]].

== References ==
{{reflist|1}}
* {{cite journal | vauthors = Prairie RL, Talalay P | title = Enzymatic formation of testololactone | journal = Biochemistry | volume = 2 | pages = 203–8 | date = 1963 | pmid = 13985909 | doi = 10.1021/bi00901a039 }}

{{Dioxygenases}}
{{Enzymes}}
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[[Category:EC 1.14.99]]
[[Category:Enzymes of unknown structure]]


{{1.14-enzyme-stub}}