View source for Aminoglycoside N6'-acetyltransferase

{{infobox enzyme
| Name       = aminoglycoside N6'-acetyltransferase
| EC_number  = 2.3.1.82
| CAS_number = 56467-65-3
| GO_code    = 0047663
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], an '''aminoglycoside N6'-acetyltransferase''' ({{EC number|2.3.1.82}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:acetyl-CoA + kanamycin-B <math>\rightleftharpoons</math> CoA + N<sub>6</sub>'-acetylkanamycin-B

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[acetyl-CoA]] and [[kanamycin B]], whereas its two [[product (chemistry)|products]] are [[coenzyme A|CoA]] and [[N6'-acetylkanamycin-B]].

This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''acetyl-CoA:kanamycin-B N6'-acetyltransferase'''. Other names in common use include '''aminoglycoside 6'-N-acetyltransferase''', '''aminoglycoside-6'-acetyltransferase''', '''aminoglycoside-6-N-acetyltransferase''', and '''kanamycin acetyltransferase'''.

==Structural studies==

As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1S3Z}}, {{PDB link|1S5K}}, {{PDB link|1S60}}, and {{PDB link|2A4N}}.

==References==
{{reflist|1}}
* {{cite journal |vauthors=Le Goffic F, Martel A | date = 1974 | title = [Resistance to [[aminoside]]s induced by an isoenzyme, kanamycin acetyltransferase] | journal = Biochimie  | volume = 56 | pages = 893&ndash;7  | pmid = 4614862 | issue = 6–7 | doi=10.1016/s0300-9084(74)80512-2}}
* {{cite journal |vauthors=Benveniste R, Davies J | date = 1971 | title = Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor | journal = Biochemistry  | volume = 10 | pages = 1787&ndash;96  | pmid = 4935296 | doi = 10.1021/bi00786a009 | issue = 10 }}
* {{cite journal | author = Dowding JE | date = 1977 | title = Mechanisms of gentamicin resistance in Staphylococcus aureus | journal = Antimicrob. Agents Chemother.  | volume = 11 | pages = 47&ndash;50  | pmid = 836013 | issue = 1 | pmc = 351917 | doi=10.1128/aac.11.1.47}}

{{Acyltransferases}}
{{Enzymes}}
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[[Category:EC 2.3.1]]
[[Category:Enzymes of known structure]]


{{2.3-enzyme-stub}}