View source for Adenylyl-(glutamate—ammonia ligase) hydrolase

{{infobox enzyme
| Name       = adenylyl-[glutamate-ammonia ligase] hydrolase
| EC_number  = 3.1.4.15
| CAS_number = 37288-22-5
| GO_code    = 0047388
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], an '''adenylyl-[glutamate---ammonia ligase] hydrolase''' ({{EC number|3.1.4.15}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H<sub>2</sub>O <math>\rightleftharpoons</math> adenylate + [L-glutamate:ammonia ligase (ADP-forming)]

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[adenylate]] and [[L-glutamate:ammonia ligase (ADP-forming)]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on phosphoric [[ester|diester]] bonds.  The [[List of enzymes|systematic name]] of this enzyme class is '''adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] adenylylhydrolase'''. Other names in common use include '''adenylyl-[glutamine-synthetase]hydrolase''', and '''adenylyl(glutamine synthetase) hydrolase'''.

==References==
{{reflist|1}}
* {{cite journal |vauthors=Heilmeyer L, Battig F, Holzer H | year = 1968 | title = Characterization of a glutamine synthetase b activating (deadenylylating) enzyme system in Escherichia coli | journal = Eur. J. Biochem.  | volume = 9 | pages = 259&ndash;262 | doi = 10.1111/j.1432-1033.1969.tb00603.x |pmid=4897098}}
* {{cite journal | author = Shapiro BM | year = 1969 | title = The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements | journal = Biochemistry  | volume = 8 | pages = 659&ndash;70  | pmid = 4893578 | doi = 10.1021/bi00830a030 | issue = 2 }}
* {{cite journal |vauthors=Shapiro BM, Stadtman ER | year = 1968 | title = 5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli | journal = J. Biol. Chem.  | volume = 243 | pages = 3769&ndash;71  | pmid = 4298074 | issue = 13 }}

{{Esterases}}
{{Enzymes}}
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[[Category:EC 3.1.4]]
[[Category:Enzymes of unknown structure]]


{{3.1-enzyme-stub}}