View source for Acetyl-CoA hydrolase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = acetyl-CoA hydrolase
| EC_number  = 3.1.2.1
| CAS_number = 9027-54-7
| GO_code    = 0003986
| image      =
| width      = 
| caption    =  
}}
The enzyme '''acetyl-CoA hydrolase''' (EC 3.1.2.1) [[catalysis|catalyzes]] the reaction

[[File:Acetyl-CoA hydrolase.svg|center|480px]]

<div align="center"><small>acetyl-CoA + H<sub>2</sub>O <math>\rightleftharpoons</math> CoA + acetate</small></div>

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on [[thioester]] bonds.  The systematic name is '''CoA thiol esterase'''.  This enzyme participates in [[pyruvate metabolism]].

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2H4U}}.

==See also==
*[[Acetyl-CoA synthetase]] and [[ACSS2]], enzymes that perform the reverse reaction using ATP

==References==
{{reflist|1}}
* {{cite journal | vauthors = Gergely J, Hele P, Ramakrishnan CV | date = 1952 | title = Succinyl and acetyl coenzyme A deacylases | journal = J. Biol. Chem. | volume = 198 | pages = 323&ndash;334 | pmid = 12999747 | issue = 1 | doi = 10.1016/S0021-9258(18)55586-1 | doi-access = free | url = https://www.jbc.org/content/198/1/323.long }}{{Dead link|date=September 2019 |bot=InternetArchiveBot |fix-attempted=yes }}

{{Thioesterases}}
{{Esterases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 3.1.2]]
[[Category:Enzymes of known structure]]


{{3.1-enzyme-stub}}