View source for 6'-Deoxychalcone synthase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 6'-Deoxychalcone synthase
| EC_number  = 2.3.1.170
| CAS_number = 114308-23-5
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
In [[enzymology]], a '''6'-deoxychalcone synthase''' ({{EC number|2.3.1.170}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H<sup>+</sup> <math>\rightleftharpoons</math> 4 CoA + isoliquiritigenin + 3 CO<sub>2</sub> + NADP<sup>+</sup> + H<sub>2</sub>O

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[malonyl-CoA]], [[4-coumaroyl-CoA]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]], whereas its 5 [[product (chemistry)|products]] are [[coenzyme A|CoA]], [[isoliquiritigenin]], [[carbon dioxide|CO<sub>2</sub>]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]]. Deoxychalcone synthase catalyzed activity is involved in the biosynthesis of [[retrochalcone]] and certain [[phytoalexin]]s in the cells of ''[[Glycyrrhiza echinata]]'' (Russian licorice) and other leguminous plants.

This enzyme belongs to the family of [[transferase]]s, to be specific those [[acyltransferase]]s transferring groups other than aminoacyl groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)'''.

== References ==
{{reflist|1}}
* {{cite journal | vauthors = Ayabe S, Udagawa A, Furuya T | date = 1988 | title = NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract | journal = Arch. Biochem. Biophys.  | volume = 261 | pages = 458–62  | pmid = 3355160 | doi = 10.1016/0003-9861(88)90362-1 | issue = 2 }}

{{Acyltransferases}}
{{Enzymes}}
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[[Category:EC 2.3.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]


{{2.3-enzyme-stub}}