View source for 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 2-''C''-methyl-<small>D</small>-erythritol 2,4-cyclodiphosphate synthase
| EC_number  = 4.6.1.12
| CAS_number =
| GO_code    = 0008685
| image      = 
| width      = 
| caption    =  
}}
'''2-''C''-Methyl-<small>D</small>-erythritol 2,4-cyclodiphosphate synthase''' ('''MEcPP synthase''', '''IspF''', EC 4.6.1.12) is a [[zinc]]-dependent [[enzyme]] and a member of the [[YgbB N terminal protein domain]], which participates in the [[Non-mevalonate pathway|MEP pathway]] (non-mevalonate pathway) of [[Terpenoid|isoprenoid]] precursor biosynthesis. It [[catalysis|catalyzes]] the following reaction:<ref>{{Cite journal|title = Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate to 2C-methyl-d-erythritol 2,4-cyclodiphosphate|vauthors=Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Lüttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F|date = 2000|journal = Proc. Natl. Acad. Sci. USA |issue=6 |doi = 10.1073/pnas.040554697|pmid = 10694574|pmc=15955|volume=97|pages=2486–90|bibcode=2000PNAS...97.2486H|doi-access=free}}</ref>

:4-diphosphocytidyl-2-''C''-methyl-<small>D</small>)erythritol 2-phosphate <math>\rightleftharpoons</math> 2-''C''-methyl-<small>D</small>-erythritol 2,4-cyclodiphosphate + CMP

The enzyme is considered a phosphorus-oxygen lyase.  The [[List of enzymes|systematic name]] of this enzyme class is '''2-phospho-4-(cytidine 5′-diphospho)-2-''C''-methyl-D-<small>D</small>-erythritol CMP-lyase (cyclizing; 2-''C''-methyl-<small>D</small>-erythritol 2,4-cyclodiphosphate-forming)'''. Other names in common use include '''IspF''', '''YgbB''' and '''MEcPP synthase'''.

==Structural studies==

As of late 2007, 20 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1GX1}}, {{PDB link|1H47}}, {{PDB link|1H48}}, {{PDB link|1IV1}}, {{PDB link|1IV2}}, {{PDB link|1IV3}}, {{PDB link|1IV4}}, {{PDB link|1T0A}}, {{PDB link|1U3L}}, {{PDB link|1U3P}}, {{PDB link|1U40}}, {{PDB link|1U43}}, {{PDB link|1VH8}}, {{PDB link|1VHA}}, {{PDB link|1W55}}, {{PDB link|1W57}}, {{PDB link|1YQN}}, {{PDB link|2AMT}}, {{PDB link|2GZL}}, and {{PDB link|2PMP}}.

==References==
<references />

{{Non-mevalonate pathway enzymes}}
{{Phosphorus-oxygen lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 4.6.1]]
[[Category:Enzymes of known structure]]


{{lyase-stub}}