View source for 2',3'-cyclic-nucleotide 2'-phosphodiesterase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 2′,3′-cyclic-nucleotide 2′-phosphodiesterase
| EC_number  = 3.1.4.16
| CAS_number = 9037-18-7
| GO_code    = 0008663
| image      =
| width      = 
| caption    =  
}}
The enzyme '''2′,3′-cyclic-nucleotide 2'-phosphodiesterase''' (EC 3.1.4.16) [[catalysis|catalyzes]] the reaction

:nucleoside 2′,3′-cyclic phosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> nucleoside 3′-phosphate

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on phosphoric [[ester|diester]] bonds.  The [[List of enzymes|systematic name]] is '''nucleoside-2′,3′-cyclic-phosphate 3'-nucleotidohydrolase'''. Other names in common use include '''ribonucleoside 2′,3′-cyclic phosphate diesterase''', '''2′,3′-cyclic AMP phosphodiesterase''', '''2′,3′-cyclic nucleotidase''', '''cyclic 2′,3′-nucleotide 2′-phosphodiesterase''', '''cyclic 2′,3′-nucleotide phosphodiesterase''', '''2′,3′-cyclic nucleoside monophosphate phosphodiesterase''', '''2′,3′-cyclic AMP 2′-phosphohydrolase''', '''cyclic phosphodiesterase:3′-nucleotidase''', '''2′,3′-cyclic nucleotide phosphohydrolase''', '''2′:3′-cyclic phosphodiesterase''', and '''2′:3′-cyclic nucleotide phosphodiesterase:3'-nucleotidase'''.  This enzyme participates in [[purine metabolism]] and [[pyrimidine metabolism]].

==References==
{{reflist|1}}
* {{cite journal | author = Anraku Y | date = 1964 | title = A new cyclic phosphodiesterase having a 3′-nucleotidase activity from ''Escherichia coli'' B. I. purification and some properties of the enzyme | journal = J. Biol. Chem.  | volume = 239 | pages = 3412&ndash;9  | pmid = 14245396 }}
* {{cite journal | author = Anraku Y | date = 1964 | title = A new cyclic phosphodiesterase having a 3′-nucleotidase activity from ''Escherichia coli'' B. II. Further studies on substrate specificity and mode of action of the enzyme | journal = J. Biol. Chem.  | volume = 239 | pages = 3420&ndash;4  | pmid = 14245397 }}
* {{cite journal |vauthors=Center MS, Behal FJ | date = 1968 | title = A cyclic phosphodiesterase with 3′-nucleotidase activity from ''Proteus mirabilis'' | journal = [[J. Biol. Chem.]]  | volume = 243 | pages = 138&ndash;43  | pmid = 4295113 | issue = 1 }}
* {{cite journal |vauthors=Olafson RW, Drummond GI, Lee JF | date = 1969 | title = Studies on 2′,3'-cyclic nucleotide-3'-phosphohydrolase from brain | journal = Can. J. Biochem.  | volume = 47 | pages = 961&ndash;6  | pmid = 4310670 | issue = 10 | doi=10.1139/o69-151}}
* {{cite journal |vauthors=Unemoto T, Hayashi M | date = 1969 | title = Chloride ion as a modifier of 2′,3′-cyclic phosphodiesterase purified from halophilic ''Vibrio alginolyticus'' | journal = Biochim. Biophys. Acta  | volume = 171 | pages = 89&ndash;102  | pmid = 4303200 | issue = 1 | doi=10.1016/0005-2744(69)90108-9}}

{{Esterases}}
{{Enzymes}}
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[[Category:EC 3.1.4]]
[[Category:Enzymes of unknown structure]]


{{3.1-enzyme-stub}}