View source for (S)-3-amino-2-methylpropionate transaminase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = (S)-3-amino-2-methylpropionate transaminase
| EC_number  = 2.6.1.22
| CAS_number = 9031-95-2
| GO_code    = 0047298
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''(S)-3-amino-2-methylpropionate transaminase''' ({{EC number|2.6.1.22}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <math>\rightleftharpoons</math> 2-methyl-3-oxopropanoate + L-glutamate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[(S)-3-amino-2-methylpropanoate]] and [[2-oxoglutarate]], whereas its two [[product (chemistry)|products]] are [[2-methyl-3-oxopropanoate]] and [[L-glutamate]].

This enzyme belongs to the family of [[transferase]]s, specifically the [[transaminases]], which transfer nitrogenous groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase'''. Other names in common use include '''L-3-aminoisobutyrate transaminase''', '''beta-aminobutyric transaminase''', '''L-3-aminoisobutyric aminotransferase''', and '''beta-aminoisobutyrate-alpha-ketoglutarate transaminase'''.  This enzyme participates in [[valine, leucine and isoleucine degradation]].

==References==
{{reflist|1}}
* {{cite journal |vauthors=Kakimoto Y, Kanazawa A, Taniguchi K, Sano I | date = 1968 | title = Beta-aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta-aminoisobutyric aciduria | journal = Biochim. Biophys. Acta  | volume = 156 | pages = 374&ndash;80  | pmid = 5641913 | issue = 2 | doi=10.1016/0304-4165(68)90267-5}}
* {{cite book |vauthors=Tamaki N, Sakata SF, Matsuda K | chapter = Purification, Properties, and Sequencing of Aminoisobutyrate Aminotransferases from Rat Liver | date = 2000 | title = Branched-Chain Amino Acids, Part B | volume = 324 | pages = 376&ndash;89  | pmid = 10989446 | doi = 10.1016/S0076-6879(00)24247-X | series = Methods in Enzymology | isbn = 978-0-12-182225-5 }}

{{Nitrogenous transferases}}
{{Enzymes}}
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[[Category:EC 2.6.1]]
[[Category:Enzymes of unknown structure]]


{{2.6-enzyme-stub}}